Radiation therapy for Sister Mary Joseph's Nodule: A review

PurposeUmbilical metastasis, known as Sister Mary Joseph's nodule (SMJN), is a manifestation of advanced malignant disease. Patients with SMJN usually require supportive care or palliative systemic chemotherapy. However, the increasing number older and infirm patients, radiation therapy for needed more frequently. Therefore, we conducted this review to provide insights into treatment rare condition.Methods MaterialsWe searched PubMed on October 16, 2022, obtained 275 papers which described metastatic tumors within near umbilicus, well 255 case reports series (298 patients), 20 reviews, original articles, other study types, 1 also case.ResultsThe prognosis patients extremely poor. some can survive than 2 years. The primary organs umbilical metastasis are mainly gastrointestinal tract including stomach colon, pancreas. In addition these organs, ovaries, uterine corpus, breasts major origins affected in women. Metastasis may be divided four types according tumor location mechanism extension: not although existing adjacent paraumbilical hernia sac, iatrogenic Only seven who received detail. were two groups: relatively long course high total dose (approximately 45 Gy) group short low group.ConclusionsUmbilical SMJN, disease based extent mechanism. Although poor, precisely therapy. Half treated course, whereas half doses up Gy.